Johansson [44] concluded that the addition of a genetic risk score made up of 33 common genetic variants to PSA resulted in a marginal improvement in prostate cancer prediction (520 cases, 988 controls, AUC for genetic risk score = 64.3%, AUC for PSA = 86.2%, AUC for PSA and genetic risk score = 87.2%). Here, KLK3 is linked to Familial prostate cancer.