ROC curves indicate that additionally including the 10 PSA-SNPs did not improve the performance of measured PSA as a tool for identifying high risk prostate cancer (measured PSA level AUC = 59.5% (95% CI: 54.7,64.2) vs additionally including the 4 PSA-SNPs and 10 aggressive prostate cancer SNPs AUC = 60.1% (95% CI: 55.5,64.9) (p-value = 0.43)) (Fig 2). The gene discussed is KLK3; the disease is prostate carcinoma.