There was no convincing evidence that associations of four PSA-SNPs with PSA level, previously reported in men without prostate cancer, were replicated in men with raised PSA (3-10ng/nL) and prostate cancer: none of the four PSA-SNPs were associated with PSA level in men stratified by cancer risk (high or low risk of progression) (Table 1). This evidence concerns the gene KLK3 and cancer.