ROC curves indicate that including the 4 PSA-SNPs using published coefficients does not improve the performance of measured PSA as a tool for identifying high risk prostate cancer (measured PSA level AUC = 59.5% (95% CI: 54.7,64.2) vs genetically corrected PSA risk scores using the 4 PSA-SNPs AUC = 59.8% (95% CI: 55.2,64.5) (p-value = 0.40)) (Fig 2). This evidence concerns the gene KLK3 and Familial prostate cancer.