Stratifying the analysis by age (<65years, ≥65 years) did not improve the performance of measured PSA or genetically corrected PSA risk scores as a tool for identifying high risk prostate cancer (measured PSA level: AUC in men<65 years = 57.8% (95% CI: 51.7,63.9), AUC in men≥65 years = 61.2% (95% CI: 53.7,68.7), p-for-difference = 0.49; genetically corrected PSA risk score using 4 PSA-SNPs: in men<65 years = 58.0% (95% CI: 51.9,64.1), AUC in men≥65 years = 62.0% (95% CI: 54.6,69.4), p-for-difference = 0.41). This evidence concerns the gene KLK3 and Familial prostate cancer.