For rs17632542, there was some evidence that men with “genetically” high PSA, i.e. had 1 or 2 copies of the T-allele associated with increasing PSA, had a decreased risk of prostate cancer at high risk of progression (rs17632542-T: OR per allele 0.62, CI: 0.38,1.00). The gene discussed is KLK3; the disease is Familial prostate cancer.