Additionally adding the combined effect of 4 PSA-SNPs and 10 aggressive prostate cancer SNPs (model 4) did slightly improve upon the performance of measured PSA alone (model 1) when identifying high risk prostate cancer from low risk: model 1 AUC = 59.5% (95% CI: 54.7,64.2), model 4 AUC = 63.6% (95% CI: 59.1,68.1). This evidence concerns the gene KLK3 and prostate carcinoma.