At the end of the experiment, both the treatment and control groups had statistically the same body weight, indicating minimal toxicity of phospho-bufalin.To test whether p-Buf can also cause SRC–3 down-regulation in TNBC mouse model, the SRC–3 levels in tumor tissues were detected both by Western blotting and immunohistochemistry (IHC). Here, NCOA3 is linked to neoplasm.