When we measured the effect of NF110 and NF449 on virus replication (experiments performed in serum-containing medium), NF110 inhibited replication of EV-A71-1095 in RD cells at a somewhat lower concentration than did NF449 [NF110 50% inhibitory concentration (IC50), 1 μM; NF449 IC50, 4 μM] (Fig 2C); both NF449 and NF110 inhibited infection more effectively than the parent compound, suramin (IC50 32–64 μM). The gene discussed is ILF3; the disease is infection.