Four SNPs (TLR1 rs4833095, TLR2 rs3804100, TLR6 rs5743810 and TLR9 rs352139) were associated with TB susceptibility across ethnic groups, while subgroup analysis on TLR2 rs5743708 and TLR4 rs4986791 showed significant association in the Asian and Hispanic ethnic groups. The gene discussed is TLR9; the disease is tuberculosis.