Degradation of Ikaros and Aiolos in the presence of lenalidomide was previously shown to correlate with the reduction of c-Myc and IRF4 levels in MM cell lines.20 We wanted to investigate whether the selective downregulation of IKZF1 or IKZF3 with shRNAs lead to reductions in c-Myc and IRF4 protein levels. This evidence concerns the gene IRF4 and Miyoshi myopathy.