The likely pathological rewiring of the Aiolos/Ikaros/c-Myc/IRF4 expression is further substantiated by the increased levels of c-Myc and IRF4 detected in CD138+ MM compared with normal plasma cells from bone marrow samples in the presence of elevated levels of Aiolos and Ikaros (Figures 1a and b). Here, IRF4 is linked to Miyoshi myopathy.