We analyzed the expression of IKZF1, IKZF3, c-MYC and IRF4 genes from the public data set (GSE6477) of normal (n=15), monoclonal gammopathy of undetermined significance (n=21), smoldering MM (SMM, n=23), newly diagnosed MM (n=75) and relapsed/refractory MM (n=28) samples.24c-MYC and IRF4 expression markedly increased as the disease progressed from monoclonal gammopathy of undetermined significance to SMM, to newly diagnosed MM and relapsed/refractory MM (Figure 1a), consistent with dysregulation of their expression in the progression from normal to malignant state. This evidence concerns the gene IRF4 and monoclonal gammopathy.