HDL-C levels are inversely correlated with CAD.1-3 High HDL-C levels are associated with the protection from CAD and low HDL-C levels are related with elevated risk of CAD.4 Endothelial lipase (EL) is a protein from the triglyceride lipase family which is expressed in the endothelial cells and tissues like the liver, lung, macrophage, testis, ovary and placenta. The gene discussed is DDHD2; the disease is coronary artery disorder.