Therefore, as expected, a decrease in EL expression and activity leads to increases in HDL-C levels and possibly a decrease in CAD risk.1,8,9 Jaye et al10 demonstrated that overexpression of EL in the liver by adenovirus-mediated gene transfer is negatively associated with HDL-C levels and leads to a decrease in the HDL-C level. The gene discussed is LIPG; the disease is coronary artery disorder.