Renin, a proteolytic enzyme, mainly secreted by the juxtaglomerular cells in the kidney in response to renal hypoperfusion, systemic hypotension, low plasma sodium levels and increased sympathetic outflow helps regulation of normal blood pressure and sodium homeostasis.9 Plasma renin activity among the hypertensive patients may be elevated; normal or decreased.10 Essential hypertensive patients with high PRA are at greater risk of developing stroke, cardiovascular disease (CVD) and renal complications.11 The gene discussed is REN; the disease is stroke disorder.