ESR1 and hypertensive disorder: ESR1 polymorphic genes have been studied in several illness as hypertension, coronary artery diseases and stroke.13-16 The ESR1 PvuII and XbaI polymorphisms homozygous T-A haplotype carriers elicited pre-eclampsia high risk.8 In addition, ESR1 XbaI polymorphism GG genotype was associated with low risk of fetal growth abnormality in pre-eclampsia.