ESR1 and coronary atherosclerosis: In spite of increment of estrogen levels during pregnancy; blood pressure kept normal.26,27 Low ESR1 molecules were noticed in pre-menopausal women suffered from coronary arteries atherosclerosis compared with those with normal arteries.28,29 ESR1 protect against vascular injury.30,31 As estrogen effects are mediated via estrogen receptors, variations in ESR could have an important role in pregnancy maintenance.10