In 2008, Zheng et al.8 introduced the Hangzhou criteria8, which, without the presence of macrovascular invasion and exhepatic metastasis, must fulfill one of the two following requirements: (a) total tumor diameter less than or equal to 8 cm or (b) total tumor diameter greater than 8 cm, well or moderate differentiation and a preoperative alpha-fetoprotein (AFP) level of no more than 400 ng/mL. This evidence concerns the gene AFP and neoplasm.