Miranda et al. distinguished early-onset severe asthma patients, characterized by allergen sensitivity, allergic symptoms, eosinophilia and higher serum immunoglobulin E (IgE) levels, and late-onset severe asthma subjects, with lower lung function than early-onset ones, despite a shorter duration of illness and significantly more symptoms if presenting persistent eosinophils at onset [27]. This evidence concerns the gene IGHE and Increased total eosinophil count.