Shiga toxin (Stx) is a cytotoxin similar to Shigella dysenteriae toxin type 1 (6); the two main stx gene variants are Shiga toxin 1 (stx1) and Shiga toxin 2 (stx2), which damage intestinal epithelial cells and kidneys, causing hemorrhagic colitis (HC) and hemolytic-uremic syndrome (HUS), respectively (7, 8). Here, STX1A is linked to hemolytic-uremic syndrome.