IGF1 and acromegaly: Indeed, these 25 patients' mean BMI was 29±4 kg/m2 at diagnosis of acromegaly, 31±5 kg/m2 before pegvisomant introduction (P=0.003 vs BMI at diagnosis), 33±7 kg/m2 when serum IGF1 first normalized (after 15±15 months on pegvisomant, P=0.0559 vs BMI before pegvisomant) and finally to 32±7 kg/m2 at the last assessment (after 58±21 months on pegvisomant, P=0.3 vs BMI before pegvisomant).