CLIC1 and glioblastoma: To assess the effects of CLIC1-containing EVs on GBM cell growth, we silenced CLIC1 (U87 MG siCLIC1) or overexpressed a FLAG-tagged version of CLIC1 (U87 MG CLIC1 FLAG) (Fig. 3A) in U87 MG cells, which express endogenous CLIC1.