Importantly, number of genes responsible tumor immune responses and desmoplastic reaction; Mst1r, TGFβr1, TGFβr2, VEGFa, CSF-1, SDF-2, CD44, IL-6ra, PD1, CD68, CD163, fibronection and MMPs (Tables 1 & 2) were significantly reduced. Here, CSF1 is linked to neoplasm.