Furthermore, a ChIP assay revealed much more recruitment of p65, except for the AP-1 transcription factor c-Jun, into the promoter of MMP-9 in URGCP-overexpressed NSCLC cells than in control cells, which was nearly undetectable in URGCP-silenced NSCLC cells (Fig. 6E). This evidence concerns the gene JUN and non-small cell lung carcinoma.