We also analyzed the correlation between URGCP/URG4 expression and clinicopathologic parameters, and found high URGCP/URG4 expression was correlated with advanced clinicopathologic classifications (T and N), high expression of URGCP/URG4 indicated an unfavorable overall survival and served as a high risk marker of bladder cancer, these suggested URGCP/URG4 is an unfavorable prognostic factors. The gene discussed is URGCP; the disease is urinary bladder cancer.