LG-ESSs (cases 2 and 3) harbored CNA losses with the cancer-related genes PMS2 and PTEN, while UUSs (cases 4 and 5) harbored CNA gains of POU5F1, EZR, GNAQ and SYK, and CNA losses of ARID1A, DMD, RB1, DICER1, CYLD, CDH1, TP53 and PRKAR1A. We also observed recurrent CNAs (n ≥ 2) on 11q21 (CNA loss) and 16q11.2 - q24.3 (CNA loss) (Figure 1B). The gene discussed is CYLD; the disease is cancer.