Following 48 hrs of treatment, multiparametric flow cytometry (diagrammed in Figure 5B) showed a substantial increase of Annexin V staining, specifically in the CD138+/CD38high MM cells [47, 48] treated with AR-42 in combination with Len (p < 0.0001) (Figure 5C). The gene discussed is ANXA5; the disease is Miyoshi myopathy.