ANXA5 and Miyoshi myopathy: We chose a 24-hr treatment with 0.1 μM AR-42, because we found that this treatment leads to a detectable hyperacetylation of histone 3 and 4 (Supplementary Figure S1A), but without significant increase of apoptosis, as measured by Annexin V-PI staining in all MM cell lines tested (MM.1S, U266, RPMI-8226, MM.1R) (Supplementary Figure S1B and data not shown).