Anti-angiogenesis has been a therapeutic strategy for cirrhosis and cirrhotic angiogenesis is regulated through two main pathways: overexpression of grow factors and cytokines, especially platelet derived growth factor (PDGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) in the process of hepatic chronic wound healing. Here, VEGFA is linked to Cirrhosis.