IKBKB and neoplasm: However, a recent data shows that mice with myeloid-specific IKKβ loss exhibit more rapid growth of cutaneous and lung melanoma tumors due to reduced recruitment of myeloid cells into the tumor, reduced expression of MHCII, and enhanced production of the CCL11 chemokine (negatively regulating dendritic cell maturation) and impaired CD8+T cytotoxicity.