Double staining of glioma sections with anti-IKKβ (red) and anti-HLA antibodies (green) showed a strong expression of the IKKβ protein in microglia/macrophages (HLA positive cells) in JPA, while the IKKβ immunoreactivity was low in those cells in GBM specimens (Fig. 5A, 5B). Here, IKBKB is linked to central nervous system cancer.