MRE11 and cancer: Finally, these SL interactions do not include cancer genes or genes that are frequently altered in cancers – in particular, from the examples above, ASPSCR1, BLM, SMARCB1 and MRE11A put together are altered (homozygous deletion) in < 10 % of most cancers as per The Cancer Genome Atlas (TCGA) Cbioportal cohort [41, 42] – and therefore, the proportion of cancers benefiting from targeting their SL partners is very small.