Depending on the status of certain DDR genes, our predicted genes can be oncogenic drivers (e.g. TLK2, which seems to be driving luminal breast tumours where PIK3CA expression is not high: Section 3.4), or vulnerability genes on which the survival of cells heavily depends (e.g. SMC4, which is required for structural maintenance of chromosomes and DNA repair, more so in the context of loss of key DDR genes). This evidence concerns the gene PIK3CA and breast neoplasm.