That category includes 8 genes (P = 5 × 10−3) that are involved in Epithelial mesenchymal transitions (EMT) (Supplementary Table S3A) including VIM (VIMENTIN) [8], ABL2/ARG involved in defining the balance between proliferation and invasion [9] in both cell culture and animal experiments, PAPPA [10] a protease required for invasiveness of several cancer cell lines, and uPA (urokinase), a well defined marker of invasive tumor cells that is regulated by methylation of its promoter region [11]. The gene discussed is PAPPA; the disease is cancer.