To test whether C11orf68, G0S2, SHISA2 and TMEM156 are required for the invasive phenotype of breast MDA-MB-231, liver SKHep1and prostate PC3 cancer cell lines, we used stable shRNA-mediated depletion of these genes with lentiviral particles expressing shRNA directed against these 4 genes (3 different pools of stable infected cells were tested per shRNA construct). Here, C11orf68 is linked to cancer.