Apart from the remarkable agreement in histological phenotype, the c-Myc disease mouse model mimics closely c-MYC events in human lung cancer and included over-expression of CDK4, CDC2A, TFDP1, CCNB1, CDC20, PRC1, CKS1, CKS2 and MKI67 [66, 67] and similar regulation of some related genes, e.g. up-regulation of NEK2, KIF15 and KIF2C and repression of CDKN2B [67]. This evidence concerns the gene CDK4 and lung cancer.