In total, 7 human cell lines, i.e. lymphoplastoid (GM12878), leukemia (K562), embryonic stem cell (H1-hESC), endothelial cell (HUVEC), hepatoma (HepG2), breast cancer (MCF-7), cervical carcinoma (HeLa) and two murine cell lines, i.e. B-cell lymphoma (CH12, analog of human GM12878 cell line) and leukemia (MEL, analog of human K562 cell line) were analyzed for c-Myc binding sites in promoter and other genomic regions of the differentially expressed genes that were originally identified in lung tumors of c-Myc transgenic mice. This evidence concerns the gene MYC and hepatocellular carcinoma.