This affiliation between LRP/LR expression and tumor aggressiveness proposes LRP/LR as a promising tool for cancer treatment and since the targeting of LRP/LR on cancerous cells has proven successful with regards to reduction of tumor metastasis[29, 30, 33, 37] and hampering of angiogenesis induction[34], exploring the role of LRP/LR on the viability of cancerous cells has gained huge interest. The gene discussed is RPSA; the disease is cancer.