RPSA and cancer: No significant decrease in viability of MDA-MB-231 was observed 24 h or 48 h after transfection (Fig 3), however the cell viability of the MCF-7, MDA-MB 231 and WHCO1 cancer cells was significantly decreased by 52%, 45% and 72%, respectively (Fig 4) 72 h following the downregulation of LRP/LR expression.