Post-transfection with siRNA-LAMR1 and treatment with 8mM PCA, breast MCF-7, MDA-MB 231 and oesophageal WHCO1 cancer cells labelled with Annexin V-FITC/7-AAD resulted in a shift of the majority of cells to the quadrants displaying late apoptotic and necrotic cells (Fig 5). Here, ANXA5 is linked to cancer.