MYC and colorectal carcinoma: Overexpression of c-MYC protein was detected in 201 (54.8%) of 367 CRC patients (cohort 1) and was associated with early pT stage (P < 0.001), low grade of histologic differentiation (P = 0.007), absence of perineural invasion (P = 0.025) and smaller size (P < 0.001) (Table 1).