TfR1 silencing with siRNA in Caki-1, 786-O and SN12C-GFP-SRLu2 cells (Figure 2D) significantly diminished cell proliferation (Figure 2E) and the invasiveness (Figure 2F and 2G), demonstrating that increased expression of TfR1 is involved in gain of tumorigenic and metastatic potential of RCC cells. This evidence concerns the gene TFRC and renal cell carcinoma.