IGF2 and hepatocellular carcinoma: The insulin-like growth factor 2 (IGF2) mRNA-binding protein p62/IMP2-2/IGF2BP2-2 represents a shortened splice variant of IMP2, but harboring the identical mRNA-binding domain.3 Although p62 was originally identified as an autoantigen in an HCC patient,4 a functional impact of p62 or IMP2 on hepatocarcinogenesis has not been described in detail as yet.