IGF2BP2 and cancer: The homolog of human 8q23, amplified specifically in p62 transgenic animals, is frequently gained in human HCC tissues.44 Interestingly, amplification of the homolog of human chromosome 3q, which was gained in p62 transgenic tumors, is correlated with advanced-stage disease in cervical carcinomas.45 The losses specifically observed in p62 transgenics on the homologs of human chromosomes 9q33.3-34.3, 11q23.1-24.1, 16q42.13-42.2, and 21q22.11-3 were reported to be deleted in different types of cancer including HCC.46, 47