AFP and hepatoblastoma: Regarding the classification from Boyault et al.,32IMP2-overexpressing samples probably belong to the G1 subset, which is characterized by an increased expression of AFP and the imprinted gene products IGF2 and H19. p62 transgenic mice were shown to overexpress both imprinted genes.10 Finally, IMP2-overexpressing samples match the molecular pattern of Cairo's aggressive hepatoblastoma, in which AFP, Krt19, and EpCAM are elevated.