As for the combination with TRAIL, we also obtained a broad range of tumour cell lethality responses, but we observed no correlation between TNFα sensitivity and AZD5582+TRAIL combination response (Figure 3c); interestingly, there was also no correlation between sensitivity to TNFα and AZD5582+TNFα (Figure 3d), which is in contrast to the strong correlation between TRAIL sensitivity and AZD5582+TRAIL combination effect discussed previously (Figure 3a). The gene discussed is TNFSF10; the disease is neoplasm.