Expression of Caspase-8 was also not significantly altered in resistant cell lines; this is in contrast with recently published data that identified Caspase-8 expression levels as a biomarker of TRAIL sensitivity in HNSCC,22 suggesting a potentially different mode of suppression of TRAIL receptor-dependent apoptosis in breast cancer. The gene discussed is TNFSF10; the disease is head and neck squamous cell carcinoma.