In addition, single nucleotide polymorphisms in the WRAP53 gene are associated with poor outcome in epithelial ovarian cancer18, 19 and inherited mutations in this same gene cause dyskeratosis congenita, which is associated with a dramatic elevation in risk for developing cancer.15 Since inactivation of WRAP53β by mutations in both alleles is required for development of this disease, this protein appears to be a bona fide tumor suppressor. This evidence concerns the gene WRAP53 and cancer.