Still, the involvement of WRAP53β in the repair of DNA double-strand breaks is independent of WRAP53α-mediated regulation of p53, since this also occurs in SKOV-3, H1299 and HeLa cells, which contain no or inactive p53 (Figures 3 and 4).14 Nonetheless, it remains to be determined whether the parallel actions of WRAP53α and WRAP53β are required for a complete DNA damage response that protects against tumor development and/or progression. The gene discussed is TP53; the disease is neoplasm.