Multivariate analysis including nuclear expression of WRAP53β and stage, differentiation grade, histology and p53 expression of the tumors revealed that low WRAP53β expression was associated with a 4-fold higher risk of dying from ovarian cancer and demonstrated that WRAP53β is an independent marker of survival in patients with ovarian cancer (HR=4.20, 95% CI=1.00–17.61, P=0.05; Table 2). This evidence concerns the gene TP53 and ovarian cancer.