Some studies revealed that LDHB could enhance proliferation in a subset of lung adenocarcinoma and breast cancer.15–17 Other studies demonstrated that the expression of LDHB was suppressed in pancreatic cancer, prostate cancer, and gastric cancer.9,18,19 However, less definitive evidence has been reported in HCC, and the link between LDHB and HCC development is poorly understood. This evidence concerns the gene LDHB and Familial prostate cancer.