The linkage disequilibrium block that contains SNP rs4977574 harbors a gene that encodes a large antisense noncoding RNA (ANRIL), which is expressed in endothelial cells.37,38 Expression of ANRIL is associated with atherosclerosis and may be involved in the regulation of the cyclin-dependent kinase inhibitor 2A and 2B genes.39,40 The MTAP gene, which encodes methylthioadenosine phosphorylase, an essential enzyme in polyamine metabolism, has also been found to be associated with atherosclerosis. This evidence concerns the gene MTAP and atherosclerosis.