However it is important and interesting to note here that the drastic expansion of the granulocytic MDSCs (CD11b+Ly6G+) after 4T1 tumor inoculation (from 5.1% in normal mice to 53.5% in PBS treated mice) was not able to be reversed by the combined treatment of rapamycin and SK-TCL-mDCs (i.e., 49.7%), suggesting that a portion of the tumor metastasis-mediated granulocytic MDSC expansion can not be rescued by the activity of test DC vaccine. Here, ITGAM is linked to neoplasm.