Also, despite the prominent role of CD4+ and CD8+ T cells in contributing to serum IFN-γ levels during malaria, γδ T cells in mice are able to control liver stage Plasmodium infection in the absence of αβ T cells [19], demonstrating that γδ T cells are an important source of IFN-γ with respect to parasite control. This evidence concerns the gene CD4 and malaria.