Additionally, candidate tumor suppressors retinoic acid receptor responder (tazarotene induced) 1 (RARRES1), which encodes Tazarotene-induced gene-1 TIG1; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) (DAB2); Ras association (RalGDS/AF-6) domain family member 1 (RASSF1); and FEZ family zinc finger 2 (FEZF2) were shown to be down-regulated through a DNA hypermethylation-mediated mechanism in nasopharyngeal carcinoma [16,17,18,19]. Here, RARRES1 is linked to nasopharyngeal carcinoma.