The epigenetic repression of tumor suppressors, Breast cancer 1 (BRCA1); PYRIN-PAAD-DAPIN domain (PYD) and caspase-recruitment domain (CARD) domain containing (PYCARD) which encodes Apoptosis-associated speck-like protein containing a CARD (ASC); and Suppressor of Cytokine Signaling (SOCS), can greatly contribute to cancer progression [13,14,15]. The gene discussed is CISH; the disease is cancer.