HIF mediates transcriptional activation of a plethora of genes including, glucose transporter protein type 1 (GLUT1), vascular endothelial growth factor (VEGF), BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) and lysyl oxidase (LOX) [65,66], which are involved in a variety of cellular functions that promote tumor progression. Here, VEGFA is linked to neoplasm.