SMO and prostate carcinoma: Given the potential clinical benefits seen with high-dose itraconazole in the CRPC setting that were associated with Hedgehog pathway inhibition in skin biopsies, and the relatively mild toxicity profiles in early-phase trials of more potent SMO inhibitors (intolerable grade-2 adverse events including dysgeusia, muscle spasms, and alopecia are notable), there has been increased interest in evaluating the clinical utility of these inhibitors in men with prostate cancer.