Our study is the first to describe a novel effect of thyroid disorder or DPP extract on testicular marker enzymes: SDH and LDH are involved in the maturation and energy metabolism of spermatogenic cells and spermatozoa [52], ALP plays critical role in spermatogenic cells glucose uptake and division [53], ACP is one of the markers of testicular steroidogenesis [54] and G6PD provides reducing equivalents for steroidogenesis [52, 55]. This evidence concerns the gene NDUFAB1 and thyroid gland disorder.