Hu et al. have found that developing lung cancer between 3 and 5 years of CT screening more frequently involves increased gene expression of β Integrins (ITGB1), as shown in Fig. 5, where ITGB1 directly interacts with Integrin-linked kinase (ILK) and phosphorylates AKT in a PI3K-dependent manner (Hu et al., 2015). The gene discussed is ITGB1; the disease is lung cancer.