MCL1 and posterior cortical atrophy: Our results in TRAMP mice suggested that the differences in the final primary PCa weights between the 1198+BA combination and BA alone was not due to changes in apoptosis, angiogenesis or proliferation but instead due to decreased Mcl-1, increased DNA damage (γH2AX IHC), and likely increased necrotic cell death (Figures 2, 3).