TNC and prostate neoplasm: Both in vitro and in vivo TPIN-SC and TLN-SC, and not CSC obtained from frank prostate tumors, used Tenascin-C (TNC), an extracellular matrix protein of stem cell niches [7], to interact with α5β1 integrin on the cell surface of both human and murine T cells, thus inhibiting T cell receptor-dependent activation, proliferation and cytokine production [5].