Clinical data of the following were reviewed:(a) a patient with hypoparathyroidism before and during chronicdialysis; (b) patients on dialysis with surgically createdhypoparathyroidism; (c) dialysis patients being treated with Cinacalcet,a calcium-sensing receptor agonist that lowers parathyroid hormone (PTH) levels; and(d) dialysis patients being treated with Velcalcetide, a newcalcium-sensing receptor agonist that also lowers PTH. The gene discussed is PTH; the disease is hypoparathyroidism.