APC and neoplasm: The first known description of multiple colorectal polypoid lesions was described in 1721 in Latin by Menzel in a German medical journal, and the first reported case of FAP was around 125 years ago.8,9 A mutation in the APC gene, a tumor suppressor gene discovered in 1987 and on chromosome 5q21-22, is responsible for this autosomal dominant syndrome of incidence 1/9000.10 A study of 156 FAP patients demonstrated APC gene mutations in 80%; the most frequent mutation comprised 1 to 5 base pair deletions leading to stop codons and truncated proteins.11