ESR1 and pancreatic intraductal papillary-mucinous neoplasm: 14 TFs which have target genes in these clusters were detected, and TFs enrichment analysis showed that three TFs (ESR1, ERG, and FLI1) were selectively enriched in cluster 1 (as shown in Table 2 and Figure 4), suggesting that these three TFs and their corresponding target genes may play important roles in early stages of IPMN progression, but these three TFs in IPMN progression have not yet received much attention and research.