ESR1 and pancreatic intraductal papillary-mucinous neoplasm: As in the results showed in Figure 5, the mRNA levels of ESR1, ERG, and FLI1 were remarkably decreased between NT and IPMA (t-test, P < 0.05) and then continuously and slightly decreased during IPMN progression, which confirmed the results of the microarray analysis and TFs enrichment analysis.