The prognostic and diagnostic values of the CSF levels of phosphorylated neurofilament heavy chain and complement C3 (pNFH/C3) were also confirmed in patients with ALS, and the predictive pNFH/C3 ratio identified ALS with 87.3 % sensitivity and 94.6 % specificity [12]. Here, NEFH is linked to amyotrophic lateral sclerosis.