CDH1 and hepatocellular carcinoma: In a different study on paraffin-embedded hepatocellular carcinoma tissues (n = 113) and their corresponding peritumoral normal tissues (n = 106), although the expression of 3-EMT-related proteins, S100A4, vimentin, and E-cadherin was studied, the authors reported that E-cadherin alone can be used as a direct prognosticator of negative outcome [54].