NUP214 and acute myeloid leukemia: DEK is a highly conserved chromatin-associated, nonhistone phosphoprotein (43 kDa) that was originally identified as part of a fusion protein (DEK-CAN) in an acute myeloid leukemia (AML) subtype with translocation t(6;9), a balanced translocation, which confers a poor prognosis [19–21].