TP53 and head and neck squamous cell carcinoma: Also, some of the antitumor effects shown by p53 are mediated through miR-145 since the abrogation of miR-145 in p53-over-expressed cells reversed the inhibition of p53 on migration, invasion, EMT and stemness of PC3 cells [81, 82] and also could be a reason for suppression of cell growth in vitro and in vivo in HNSCC [50] and breast cancer cells [83].