KLK3 and Familial prostate cancer: The reduced miR-145 expression in prostate cancer (PCa) samples correlated with higher Gleason score, advanced stage, tumor size, higher prostate-specific antigen (PSA) and significantly shorter disease-free survival (DFS) for the PCa patients [45] and also associated with poor prognosis, lymph node metastasis and advanced stage in cervical cancers [46].