Furthermore, recent studies have shown that CXCL8 levels are significantly elevated in the blood in COPD patients, and that CXCL8 (as well as CCL4) levels correlate with mortality, exacerbation rate, and BODE scores, and inversely correlate with FEV1 and DLCO [24–26]. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.