However, in germline Hace1–/– knockout mice, a predisposition for late-onset cancer and hypersensitivity to different carcinogenic factors was reported.11 In a child with bilateral, early-onset Wilms’ tumour, Slade et al14 identified a t(5;6)(q21;q21) translocation transecting HACE1. The gene discussed is HACE1; the disease is Wilms tumor.