Collectively POLR3B, ETFA, VTI1A, ZBTB16 and PHLDA1 are altered in 8% (22/286) of LGG as compared with 3% (8/273) of GBM (P=0.014, Supplementary Table 7) providing support for these genes having a role in glioma tumorigenesis. This evidence concerns the gene ZBTB16 and central nervous system cancer.