F8 and central nervous system cancer: For example, a recent prospective study by Thaler et al. investigated 11 potential biomarkers for predicting VTE risk in 144 newly diagnosed adult high grade glioma patients found significant associations between future VTE risk and leukocyte count, platelet count, sP-selectin, prothrombin fragment 1 + 2 (F 1 + 2), FVIII activity, and D-dimer21.